Prof. Maffulli has published more than 900 peer-reviewed articles in scientific journals and 12 books on Orthopaedic Surgery and in Sports Medicine. Prof. Maffulli has a particular scientific interest in the physiopathology of sports injuries, including anterior cruciate ligament and tendon injuries, and great expertise in arthroscopic techniques of the knee and foot and ankle.

He was Professor of Trauma and Orthopaedic Surgery at Keele University School of Medicine (2001-2008), Centre Lead and Professor of Sports and Exercise Medicine, at Queen Mary University of London, Barts and The London School of Medicine and Dentistry, London (2008-2013), and has now taken up the Chair in Musculoskeletal Disorders in Salerno University School of Medicine, Italy, maintaining an Honorary Chair in Sport and Exercise Medicine at Queen Mary University of London, and a Visiting Professorship in Trauma and Orthopaedic Surgery at Keele University School of Medicine.

A keen athlete in his younger days, his old dream of going to the Olympics has been granted in London: he has been the Field of Play doctor for the Olympic Wrestling Tournament, and has lead a group of seven orthopedic surgeons to administer the Orthopaedic Foot and Ankle care for both the Olympics and the Paralympics. He is one among a small handful of surgeons to have been awarded the FRCP.