Spondylarthritis (or Seronegative spondyloarthritis) or SPA

Spondylarthritis (or Seronegative spondyloarthritis) or SPA is the name for a family of inflammatory rheumatic diseases that includes ankylosing spondylitis; undifferentiated spondylarthritis;  reactive arthritis (known previously as Reite,  syndrome);
psoriatic arthritis; and arthritis associated with the   inflammatory   bowel   diseases,  ulcerative  colitis, and Crohn’s disease.

FAST FACTS

  • The major symptom in most patients is inflammatory low back This means pain is worse with rest and better with activity. Pain can cause patients to wake up at night and be associated with morning stiffness. In a minority of patients, the major symptom is pain and swelling in the arms and legs. This type of spondylarthritis is known as peripheral spondylarthritis.
  • The prototype of spondylarthritis  known  as ankylosing spondylitis, which more commonly usually strikes young
  • Nonsteroidal anti-inflammatory drugs (commonly called NSAIDs) offer considerable symptom relief in most TNF blockers are effective in patients that do not respond adequately to NSAIDs.
  • Regular recreational activities and back exercises are

WHAT  IS SPONDYLARTHRITIS?

Spondylarthritis is different from other types of arthritis in that it also involves the entheses, where ligaments and tendons are attached to bones. There are two major types of presentations. The first is inflammation causing pain and stiffness of the spine and, in some, pain and swelling of the arms and legs. The second type is bone destruction causing deformities of the spine and disabilities of the shoulders and hips.

WHAT  CAUSES SPONDYLARTHRITIS?

In ankylosing spondylitis, the most common type of spondylarthritis, the disease is caused by multiple genes. At least 14 of these genes have been identified. The major gene is HLA-B27. Almost all Caucasian ankylosing spondylitis patients are carriers of HLA-B27. Recent studies have provided clues as to how HLA-B27 induces spondylarthritis, although this still is a subject of intense research.

WHO GETS SPONDYLARTHRITIS?

Ankylosing spondylitis usually starts in the teens and 20s and strikes males 2 – 3 times more frequently than women. Family members are at higher risk, depending partly on the HLA-B27 gene.

HOW IS SPONDYLARTHRITIS DIAGNOSED?

Correct diagnosis requires a physician to evaluate the patient’s history and do a physical examination. Thephysicianalsomaydotwoother types of evaluation. One is ordering an X-ray of the sacroiliac joints, a pair of joints in the pelvis. X-ray changes of the sacroiliac joints known as sacroiliitis  is a key  sign of  spondylarthritis.  If X-rays do not show adequate changes, but the symptoms are highly suspicious, a physician might decide to visualize the sacroiliac joints with MRI. Besides imaging, the second type of supplementary tests are blood tests for HLA-B27, and sometimes also for acute phase reactants such as C-reactive protein. Ultimately, diagnosis relies on the judgment of the attending physician. There are people who have a positive HLA-B27 gene test, but do not have arthritis and never develop arthritis. Therefore, a positive test does not mean that someone will develop spondylarthritis in the future.

HOW IS SPONDYLARTHRITIS TREATED?

Physical therapy and joint-directed  exercises  are recommended for all patients. Smoking aggravates  spondylarthritis.

There are many drug treatment options. The first lines of treatment are the NSAIDs, such as etoricoxib, naproxen, ibuprofen, meloxicam or indomethacin. No one NSAID is considered superior to another. Given in the correct dose and duration, these in and of themselves will generate considerable relief for most patients.

For localized joint swelling, injections of corticosteroid medications into joints or tendon sheaths can be rapidly effective.

For those resistant to the above lines of treatment, disease modifying anti-rheumatic drugs (commonly called DMARDs) such as sulfasalazine might be effective,  particularly  in those with arthritis affecting the joints of the arms and legs.

Although they may be effective, corticosteroids taken by mouth are not recommended, because the doses required will lead to many side effects.

Antibiotics are considered only for those with reactive arthritis.

TNF alpha blockers (one of the drugs known as biologics) have been shown to be very effective in treating both the spinal and peripheral joint symptoms of spondylarthritis. The TNF alpha blockers currently approved by the FDA for use in ankylosing spondylitis are:

  • Infliximab (Remicade), which is used at a dose of 5 mg/kg given intravenously every 6 –
  • etanercept (Enbrel), given 50 mg by injection under the skin once weekly;
  • Adalimumab (Humira), injected at a dose of 40 mg every other week under the skin; and
  • Golimumab (Simponi), injected at a dose of 50 mg, once a month under the

LIVING WITH SPONDYLARTHRITIS

Despite the pain, fatigue and stiffness that can be continuous or intermittent, most patients with spondylarthritis lead productive lives with normal longevity, particularly with the newer treatments available. Regular exercise is essential to maintain joint and cardiovascular health. Swimming and yoga are the best forms of exercise.

POINTS TO REMEMBER

  • Spondylarthritis is a type of arthritis that attacks the spine and in some, the joints of the arms and It can be associated with involvement of the skin, intestines, and eyes.
  • Those in their teens and 20s, particularly males, are affected most Family members of spondylarthritis patients are at higher risk.
  • Newer treatments have helped a great deal in controlling the symptoms and signs